Leap Forward in Efforts to Develop Treatments for Huntington's Disease
Research reveals that an enzyme linked with many disorders - including cancer, stroke and rheumatoid arthritis - is also involved in the generation of the toxic fragments in Huntington's disease.
View ArticleHuman Induced Pluripotent Stem Cells Successfully Used to Treat Parkinson's...
Researchers at the Buck Institute for Age Research have successfully used human induced pluripotent stem cells (iPSCs) to treat rodents afflicted with Parkinson's Disease (PD). The research validates a...
View ArticleA New Role for Insulin in Cell Survival, Cell Metabolism and Stress Response
Researchers at the Buck Institute for Age Research have discovered a novel way in which insulin affects cell metabolism and cell survival. Surprisingly the insulin signaling pathway, which is involved...
View ArticleNovel Method Results in Promising Drugs for Huntington's Disease Therapy
Buck Institute, Yale University and University of California, Berkeley scientists identify three caspase inhibitors that block HD-associated neuronal damage in cell culture; follow up experiments are...
View ArticleBay Area Philanthropist Invests $3.5 Million in Buck Faculty
Douglas Rosenberg sets $10 million goal for fund to develop treatment based on promising small molecule screening.
View ArticleCommon Lab Dye Is a Wonder Drug - for Worms
Basic Yellow 1, a dye used in neuroscience labs around the world, is a wonder drug for nematode worms. Thioflavin T extended lifespan in healthy worms by more than 50 percent and slowed the disease...
View ArticleEndocannabinoid Signaling in Dietary Restriction and Lifespan Extension
Buck Institute study in Nature identifies novel metabolic signaling pathway in worms that coordinates the aging response to nutrient availability. Results provide missing piece of DR puzzle.
View ArticleLithium Profoundly Prevents Brain Damage Associated with Parkinson's
Buck Institute research in mice moves into preclinical stage; Buck working toward human trials.
View ArticleResearchers Flip the Switch Between Development and Aging in C. elegans
When researchers at the Buck Institute dialed back activity of a specific mRNA translation factor in adult nematode worms they saw an unexpected genome-wide response that effectively increased activity...
View ArticleBuck Institute and Biotica Investigate Polyketides in Extension of Healthy...
The partnership, aimed at drug development, builds on observations that rapamycin extends healthy lifespan in several species.
View ArticleNeed an Excuse to Book a Massage? Research Shows It Reduces Inflammation and...
About 18 million individuals undergo massage therapy annually in the U.S. Despite several reports that long-term massage therapy reduces chronic pain and improves range of motion in clinical trials,...
View Article"Healthspan Campaign" Focuses on Aging as Common Denominator of Chronic Disease
Alliance for Aging Research and the Buck Institute for Research on Aging urge support for research agenda aimed at extending healthy years of life. Nearly 70 prominent scientists endorse the plan and...
View ArticleModifying Scar Tissue Can Potentially Improve Outcome in Chronic Stroke
New research from the Buck Institute, built on spinal cord injury research, shows that modifying the scar tissue that develops following a stroke is a promising avenue for future treatments. The need...
View ArticleScientists Correct Huntington's Mutation in Induced Pluripotent Stem Cells
Researchers at the Buck Institute for Research on Aging have corrected the genetic mutation responsible for Huntington's Disease (HD) using a human induced pluripotent stem cell (iPSC) that came from a...
View ArticlePhysical Activity Needed To Reap Benefits Of Dietary Restriction
Dietary restriction alone does not extend lifespan - at least in fruit flies. Flies, which share many genetic similarities with humans, need physical activity in order to live longer on a Spartan diet....
View ArticleRapamycin Effective in Mouse Model of Inherited Heart Disease and Rare...
Rapamycin, an FDA-approved immunosuppressant drug under study in aging research labs, improved function and extended survival in mice suffering from a genetic mutation which leads to dilated...
View ArticleGenome-Scale Study ID's Hundreds of Drug Targets for Huntington's
Scientists seeking to develop treatments for Huntington's disease just got a roadmap that could dramatically speed their discovery process. Researchers at the Buck Institute have used RNAi technology...
View ArticleLifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease...
Mice suffering from age-related heart disease saw a significant improvement in cardiac function after treatment with the FDA-approved drug rapamycin for just three months. Research at the Buck...
View ArticleResearch in Fruit Flies Provides New Insight Into Barrett's Esophagus
Research focused on the regulation of the adult stem cells that line the gastrointestinal tract of Drosophila suggests new models for the study of Barrett's esophagus. Barrett's esophagus is a...
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