Buck Institute and Biotica Investigate Polyketides in Extension of Healthy...
The partnership, aimed at drug development, builds on observations that rapamycin extends healthy lifespan in several species.
View ArticleNeed an Excuse to Book a Massage? Research Shows It Reduces Inflammation and...
About 18 million individuals undergo massage therapy annually in the U.S. Despite several reports that long-term massage therapy reduces chronic pain and improves range of motion in clinical trials,...
View Article"Healthspan Campaign" Focuses on Aging as Common Denominator of Chronic Disease
Alliance for Aging Research and the Buck Institute for Research on Aging urge support for research agenda aimed at extending healthy years of life. Nearly 70 prominent scientists endorse the plan and...
View ArticleModifying Scar Tissue Can Potentially Improve Outcome in Chronic Stroke
New research from the Buck Institute, built on spinal cord injury research, shows that modifying the scar tissue that develops following a stroke is a promising avenue for future treatments. The need...
View ArticleScientists Correct Huntington's Mutation in Induced Pluripotent Stem Cells
Researchers at the Buck Institute for Research on Aging have corrected the genetic mutation responsible for Huntington's Disease (HD) using a human induced pluripotent stem cell (iPSC) that came from a...
View ArticlePhysical Activity Needed To Reap Benefits Of Dietary Restriction
Dietary restriction alone does not extend lifespan - at least in fruit flies. Flies, which share many genetic similarities with humans, need physical activity in order to live longer on a Spartan diet....
View ArticleRapamycin Effective in Mouse Model of Inherited Heart Disease and Rare...
Rapamycin, an FDA-approved immunosuppressant drug under study in aging research labs, improved function and extended survival in mice suffering from a genetic mutation which leads to dilated...
View ArticleGenome-Scale Study ID's Hundreds of Drug Targets for Huntington's
Scientists seeking to develop treatments for Huntington's disease just got a roadmap that could dramatically speed their discovery process. Researchers at the Buck Institute have used RNAi technology...
View ArticleLifespan-Extending Drug Given Late in Life Reverses Age-Related Heart Disease...
Mice suffering from age-related heart disease saw a significant improvement in cardiac function after treatment with the FDA-approved drug rapamycin for just three months. Research at the Buck...
View ArticleResearch in Fruit Flies Provides New Insight Into Barrett's Esophagus
Research focused on the regulation of the adult stem cells that line the gastrointestinal tract of Drosophila suggests new models for the study of Barrett's esophagus. Barrett's esophagus is a...
View ArticleHalloween Candy Spooks Aging Digestive Systems! Research in Fruit Flies Helps...
Have you ever wondered why young children can eat bags of Halloween candy and feel fine the next day - compared to adults who experience all sorts of agony following the same junk food binge? Evolution...
View ArticleMajor Alzheimer's Risk Factor Linked to Red Wine Target
The major genetic risk factor for Alzheimer's disease, present in about two-thirds of people who develop it, is ApoE4, the cholesterol-carrying protein that about a quarter of us are born with. But one...
View ArticleUSC and Buck Institute Launch Nation's First PhD Program in Biology of Aging
To tackle the rising prevalence of age-related diseases and the challenges and opportunities presented by a growing elderly population, the USC Davis School of Gerontology and the Buck Institute for...
View ArticleAging Impacts Epigenome in Human Skeletal Muscle
Our epigenome is a set of chemical switches that turn parts of our genome off and on and are impacted by environmental factors including diet, exercise and stress. Research at the Buck Institute...
View ArticleSignaling From Dysfunctional Mitochondria Induces Cellular Senescence with a...
Finding provides alternative explanation for the free-radical theory of aging and suggests new role for mitochondria in affecting physiology.
View ArticleA surprising new role for ApoE offers explanation for its diverse range of...
Buck Institute/UCLA study finds that apolipoprotein E enters the nucleus and binds to promoter region of 1700 genes.
View ArticlePre and Post Testing Show Reversal of Memory Loss From Alzheimer's Disease in...
Small trial from the Buck Institute and UCLA succeeds using systems approach to memory disorders.
View ArticleA New Look at Vitamin D Challenges the Current View of Its Benefits
Research in C. elegans shows the popular supplement engages longevity genes to increase lifespan and prevent the accumulation of toxic proteins linked to many age-related diseases
View ArticleA new predictive model helps identify those at risk for severe COVID-19
Researchers at the Buck Institute analyzed data from the COVID-19 Symptom Tracker app used by 3 million people in the United Kingdom, adding the use of immunosuppressant medication, use of a mobility...
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